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Symposium 2010, National Institutes of Healt, Bethesda, USA -

Brain, Blood and Iron; Joint International Symposium on Neuroacanthocytosis and Neurodegeneration with Brain Iron Accumulation

The 5th symposium on neuroacanthocytosis was held in October 2010 at the National Institutes of Health, Bethesda, USA and is endorsed by the Movement Disorders Society. It was supported by an NIH grant and organised by Ruth Walker, MB, ChB, PhD, and Susan Hayflick, MD. It focused on the bridging between the neuroacanthocytosis syndromes with a special focus on neurodegeneration with brain iron accumulation.

October 1st
9.00 Welcome and General Introduction Adrian Danek, MD, Neurologische Klinik, Ludwig Maximilans University, Munich, Germany

1: Observations from the clinic
9.10 The neuroacanthocytosis syndromes Ruth H. Walker, MB, ChB, PhD, Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx and Mount Sinai Medical School, New York, NY, USA
9.30 The neurodegeneration with brain iron accumulation syndromes Susan J. Hayflick, MD, Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA
9.50 Questions for and from basic science Rainer Prohaska, PhD, Max F Perutz Laboratories, Medical University of Vienna, Vienna, Austria

10.10 Discussion

2: The fate of red blood cells
10.50 Early erythropoiesis Mohandas Narla, DSc, Kimbal Research Institute, New York Blood Center, New York, NY, USA
11.10 Maturation of reticulocytes by autophagy Mondira Kundu, MD, PhD, St. Jude Children's Research Hospital, Memphis, TN, USA
11.30 Red cell aging Lucia de Franceschi, MD, PhD, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
11.50 Determinants of red cell shape Lesley J. Bruce, PhD, Bristol Institute of Transfusion Services, Bristol, UK

12.10 Discussion and lunch

3: Mitochondria, iron, and neurodegeneration
1.30 Mitochondria in cellular iron homeostasis Alex Sheftel, PhD, University of Marburg, Marburg, Germany
1.50 Mitochondrial defects in fumble fly and pantethine rescue Ody Sibon, PhD, Department of Radiation and Stress Cell Biology, University of Groningen, Groningen, The Netherlands
2.10 Mitochondrial ferritin in neurodegeneration Sonia Levi, PhD, Vita-Salute San Raffaele University, Milan, Italy
2.30 MIN and NBIA Tobias Haack, PhD, Ludwig Maximilians University, Munich, Germany

2.50 Discussion and poster session

5.00 Pre-dinner reception. Speakers - Iron and neurodegeneration Tracey Rouault, MD, Section on Human Iron Metabolism, Molecular Medicine Program, NIH, Bethesda, MD, USA
Cellular CoA defects Grant A. Mitchell, MD, Service of Medical Genetics, Hôpital Sainte-Justine, Montreal, Canada

October 2
4: Membrane trafficking and turnover (1) lipids and phosholipase
9.00 Mechanisms of membrane trafficking Kai Simons, MD, Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
9.20 CoA metabolism and consequences of reduced CoA Suzanne Jackowski, PhD, Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA
9.40 Role of PLA2s in neuronal mitochondrial lipid metabolism and membrane structure Paul T. Kotzbauer, MD, PhD, Molecular Biology and Pharmacology, George Washington School of Medicine, St. Louis, MO, USA
10.10 iPLA2 in synaptic vesicle trafficking Kevin L. Seburn, PhD, The Jackson Laboratory, Bar Harbor, ME, USA
10.30 Alteration of autophagy in the brain of the INAD animal model Alex Ma, PhD, Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY, USA

10.50 Discussion

5: Membrane trafficking and turnover (2) VPS functions
11.30 A Direct Requirement for Vps13p in TGN to Late Endosome Trafficking in Yeast Robert S. Fuller, PhD, Biological Chemistry, University of Michigan, Ann Arbor, USA
11.50 Functions of the VPS family Antonio Velayos Baeza, PhD, Wellcome Centre for Human Genetics University of Oxford, Oxford, UK
12.10 Zebrafish vacuolar protein sorting (Vps39) and endosome trafficking Ralf Dahm, PhD, Spanish National Cancer Research Centre, Madrid, Spain

12.30 Discussion and lunch

6: Autophagy in neurodegenerative disease
1.40. Autophagy and neurodegeneration Zhenyu Yue, PhD, Molecular & Cellular Neurobiology Laboratory, Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
2.00 Multivesicular bodies in neurodegeneration Scott D. Emr, PhD, Weill Institute for Cell and Molecular Biology & Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY
2.20 Formation and regulation of autophagosomes in health and disease Fulvio Reggiori, PhD, Cell Microscopy Center, Utrecht, The Netherlands

2.40 Discussion

3.00 Discussion to develop Research Strategic Plan for NBIA and NA

5.00 Closing summary and future directions

Sponsored by National Institute of Neurological Diseases and Stroke, Office of Rare Diseases Research, and National Institute of Child Health and Human Development.