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Euro Huntington's disease network [logo]
EHDN 2004 - Programme -

Thursday, September 30th, 2004 - Welcome

18.00-21.00 Registration

Please hang up posters at the library of the Conference Center. They will be exposed throughout the meeting
21.00 Dinner at the respective hotels/at the conference center

Friday, October 1st - Euro-HD-Network and Clinical Sciences

7.30-8.30 Breakfast at the respective hotels/at the confenerce cente
8.30-9.00 Transfer from hotels to meeting place
9.00-9.10 Welcome addresses
  • J. Garcia de Yebenes on behalf of the local organising team
  • R. Blumenstein on behalf of High-Q
  • Asun on behalf of EHDA
  • G. B. Landwehrmeyer on behalf of EHDN
9.10-11.00 Euro-HD-Network - Part I
  • Spirit and concept (G. B. Landwehrmeyer)
  • Organisation (Language coordinators of EHDN)
  • Tools (T. Illmann)
  • Research goals (G. B. Landwehrmeyer)
11.00-11.45 Coffee break & Poster viewing
11.45-12.45 Euro-HD-Network - Part 2
  • Working groups (Lead facilitators)
  • Registry (G. B. Landwehrmeyer)
  • PREDICT (S. A. Johnson, J. Garcia de Yebenes)
  • Towards a constitution and publication policy - the road map (R. Blumenstein)
12.45-13.00 Opening ceremony: His Excellency Don Fernando Lamata, Secretary of Health, Ministry of Health, Spain
  • A. Martinez on behalf of EHDA
  • G. B. Landwehrmeyer on behalf of EHDN
13.00-14.00 Light lunch & Poster viewing. Announcement of working group meeting rooms and working group members.
14.00-16.00 HD - the clinical phenotype. Dimensions:
  • Motor phenotype (R. A. C. Roos)
  • Quantitative Motor testing   
    - Neurophysiological measures (R. Reilmann)   
    - Graphimetry (P. H. Kraus)
  • Cognitive phenotype (A. C. Bachoud-Levi)   
    - MRI & neuropsychological measures(Henley)
  • Behavioral/psychiatric phenotype (D. Craufurd)
    - Emotion recognition in HD(S. Simpson)
16.00-16.30 Coffee break & Poster viewing
16.30-17.00 Clinical trials in neurodegenerative disorders - a review of designs (W. Gaus)
17.00-18.30 Clinical studies and trials in HD - an update
  • Transplantation in HD (A. C. Bachoud-Levi)
  • Riluzole-(EHDI)-Trial(G. B. Landwehrmeyer)
  • LAX-101 (H. Murck)
  • COHORT and other trials conducted through the HSG (A. Shinaman)
  • SET-HD and potential trials by the Euro-HD-Network in 2005 (B. Ravina/G. B. Landwehrmeyer)
18.30-19.00 Break & Snacks
19.00-20.30 Working group meetings
21.00 Welcome reception by the Mayor of Guadarrama, Don José I. Fernandez Rubio, Centro Cultural La Torre
21.15 Chorea & music: part I: the music (A. Martinez)
22.30 Dinner Residencia Fray Luis de Leon
23.30 Transport back to the hotels

Saturday, October 2nd, 2004 - Prospects in HD

7.30-8.30 Breakfeast at respective hotels/at the conference center
8.30-9.00 Transfer from hotels to the Meeting place
9.00-11.00 Session A: Summary lecture and Datablitz: Current understanding of the pathophysiology of HD
  • Introduction(G. B. Landwehrmeyer)
  • Ubiquitination and degradation of huntington (J. Lucas)
  • Understanding poly-glutamine induced toxicity in the mouse retina (D. Devys)
  • Gene expression changes in HD brain (A. Hodges)
  • Glucose homeostasis in R6/2 (L. Hasholt)
11.00-11.30 Coffee break
11.30-13.00 Session B: Summary lectures and Datablitz: Targets for intervention    
  • Screening and testing for compounds active in HD (A. Kazantsev)
  • Cell replacement therapy (S. Dunnett)
  • Aggregation inhibitors (P. Harjes)
  • Compounds active on metabotropic glutamate receptors in HD models (J. Schiefer)
13.00-14.00 Light lunch & Poster viewing
14.00-16.00 Session C: Summary lectures and Datablitz: Markers for disease onset and disease progression    
Dry biomarkers: Imaging    
  • MRI (J. Kassubek)
  • PET (N. Leenders)
  • 11C-(R)-PK11195 PET in HD (N. Pavese)
Wet biomarkers
  • Orexin loss (Â. Petersen)
16.00-16.30 Coffee break & Poster viewing
16.30-17.15 Report of working group meetings
17.15-19.00 Session D: Summary lectures and Datablitz: Experimental compounds in model systems
  • Can flies help man to cure neurodegenerative diseases? (L. Marsh)
  • A rat model of HD (H. Ngygen)
19.00-21.00 Poster viewing with wine
21.30 Gala dinner, Residencia Fray Luis de Leon
23.00 Chorea & music: part II: the chorea (Belén y sus amigos)