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Pathogenic mechanisms -
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06.12.12A framework for cross-species data integration, model sensitivity analysis and target prioritisation in Huntington’s disease using bionetworks1.4 MBblankinapplication/pdf
06.12.12Huntington’s disease and its therapeutic target genes: a global functional profile based on the HD research crossroads database1.1 MBblankinapplication/pdf
06.12.12Systematic interactome mapping: understanding the molecular principles of neurodegenerative diseases2.1 MBblankinapplication/pdf
06.12.12AMPK activation alleviates phenotypes associated to the early phases of mutant polyQ cytoxicity1.6 MBblankinapplication/pdf
06.12.12CAG profiling in R6/1 89Q indicates early and progressive expansion in critical neuronal populations and expansion and changes in surrounding glial cell populations2.1 MBblankinapplication/pdf
06.12.12Genotoxic stress in fibroblasts and mesenchymal stem cells isolated from miniature pigs transgenic for n-terminal part of mutated human huntingtin1.3 MBblankinapplication/pdf
06.12.12Analysis of Huntingtin protein fragments in post mortem human Huntington's Disease brain tissue1.8 MBblankinapplication/pdf
06.12.12Differential sensitivity of aggregate markers in HdhQ150 and YAC128 HD mouse models1.6 MBblankinapplication/pdf
06.12.12Caspase-6 does not contribute to the proteolysis of mutant Huntingtin in the HDHQ150 knock-in mouse model of Huntington's Disease1.5 MBblankinapplication/pdf
06.12.12The role of N-terminal phosphorylation in Huntingtin´s oligomerization, aggregation and toxicity2.0 MBblankinapplication/pdf
06.12.12HDAC4 interacts with Huntingtin and HDAC4 reduction decreases cytoplamsic aggregation and rescues synaptic dysfunction in HD mouse models1.6 MBblankinapplication/pdf
06.12.12Long-term alterations in dendritic spine stability in Huntington Disease: Mechanisms underlying learning deficits in Huntington Disease?687 kBblankinapplication/pdf
06.12.12Huntingtin mediates anxiety/depression-related behaviors in mouse through BDNF transport and hippocampal neurogenesis1.6 MBblankinapplication/pdf
06.12.12CTCF in Huntington’s Disease2.0 MBblankinapplication/pdf
06.12.12Collapsin response mediator protein 4 downregulates aggregation and toxicity of mutant huntingtin1.5 MBblankinapplication/pdf
06.12.12Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation1.6 MBblankinapplication/pdf
06.12.12Glucose metabolism is reduced in Huntington Disease: in-vivo and in-vitro evidence559 kBblankinapplication/pdf
06.12.12Lactate metabolism in the Huntington's Disease mouse model R6/21.7 MBblankinapplication/pdf
06.12.12Increased glucose uptake in white adipose tissue of R6/2 mice due to changes in expression and translocation of glucose transporter 4 (GLUT4)1.7 MBblankinapplication/pdf
06.12.12Decreased expression and reduced translocation to the sarcolemma of the insulin-sensitive glucose transporter GLUT4 in skeletal muscle of R6/2 mice1.4 MBblankinapplication/pdf
06.12.12Does a peripheral immune response influence muscle pathology in Huntington’s Disease?1.6 MBblankinapplication/pdf
06.12.12Immune dysfunction in HD human myeloid cells is caused by NFkB pathway dysregulation and is reversed by lowering HTT levels1.1 MBblankinapplication/pdf
06.12.12Dysfunctional dopaminergic neurones and biphasic activitydependent dopamine release in mouse models of Huntington’s Disease1.5 MBblankinapplication/pdf
06.12.12Hyperdopaminergic status in Huntington's Disease1.6 MBblankinapplication/pdf
06.12.12Sleep and EEG abnormalities in Huntington’s Disease mice1.6 MBblankinapplication/pdf
06.12.12Neural mechanisms underlying the dysfunction of the methamphetamine-sensitive circadian oscillator (MASCO) in a mouse model of Huntington’s Disease2.1 MBblankinapplication/pdf
06.12.12Voluntary exercise improves circadian function in a mouse model of Huntington’s Disease1.5 MBblankinapplication/pdf
06.12.12Expression of mutant Huntingtin in leptin receptorexpressing neurons does not influence the metabolic phenotype and psychiatric-like features in Huntington’s Disease1.6 MBblankinapplication/pdf
06.12.12Deletion of mutant Huntingtin expression in Sim1 neurons in the BACHD mouse model of Huntington's Disease1.5 MBblankinapplication/pdf
06.12.12Copy number variation of the neuronal glucose transporter 3 and age of onset in Huntington’s Disease1.5 MBblankinapplication/pdf
06.12.12Components of the translational machinery modify toxicity in models of Huntington’s Disease1.5 MBblankinapplication/pdf

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