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application/pdfEHDN2018-Program 
Thursday, September 13th, 2018

16:00-21:00   Registration Desk

Friday, September 14th, 2018
07:30-08:30  Registration Desk
 
Welcome and Introduction
Room: Hall E
08:30-09:00   Jean-Marc Burgunder (Bern, Switzerland)
Astri Arnesen (Søgne, Norway)
 
Keynote Session I:
Past, Present, Future
Room: Hall E
Chair: Jean-Marc Burgunder (Bern, Switzerland)
Co-chair: Astri Arnesen (EHA, Norway)
 
09:00-09:20   Learning from the History of Huntington's Disease
Peter Harper (Cardiff, UK)
application/pdfslides Harper 
application/pdfDiary-of-the-Huntington-Gene-1993 
application/pdfInterview-with-Gusella-MacDonald 
 
09:20-09:40   Where are we Now
Alexandra Dürr (Paris, France)
application/pdfslides Durr 
 
09:40-10:00   The Silver Linings Playbook – A Future Outlook
Ed Wild (London, UK)
application/pdfslides Wild 
 
10:00-10:20   Living with Hope and Setbacks – a Family Perspective
Astri Arnesen (Søgne, Norway)
 
10:20-10:30   Panel discussion
 
10:30-11:00   Tea/Coffee Break

Plenary Session I:
What's New in HD Biology: Insights into Pathogenic Pathways and Therapeutic Targets'
Room: Hall E
Chair: Lesley Jones (Cardiff, UK)
Co-chair: Erich Wanker (Berlin, Germany)
 
11:00-11:20  Recent Breakthrough in Resolving the Structure of Huntingtin
Stefan Kochanek (Ulm, Germany)
application/pdfslides Kochanek 
 
11:20-11:40   Chaperone Biology and Huntington Aggregation
Harm Kampinga (Groningen, The Netherlands)
application/pdfslides Kampinga 
 
11:40-12:00  Large-Scale Functional Analysis distinguishes Pathogenic, Non-Pathogenic, and Compensatory Transcriptional Changes in HD
Juan Botas (Houston, USA)
application/pdfslides Botas 
 
12:00-12:20  Huntington’s Disease and the Genetics of CAG Repeat Expansions
Lesley Jones (Cardiff, UK)
application/pdfslides Jones 
 
12:20-12:30   Panel discussion
 
Poster Viewing
 
12:30-14:00  Poster Viewing
Room: Foyer
 
12:30-14:00   Buffet Style Lunch
 
Parallel Session I:

Parallel - Science Session:
'EHDN Projects'
Room: Hall E
Chair: Anne Rosser (Cardiff, UK)
Co-Chair: Patrick Weydt (Bonn, Germany)
 
14:00-14:10   Dysphagia in HD (Seed fund project)
Falk Schradt (Ulm, Germany)
application/pdfslides Schradt 
 
14:10-14:20   Nucleolar Activity and mHtt (Seed Fund Project)
Rosanna Parlato (Ulm, Germany)
application/pdfslides Parlato 
 
14:20-14:30   Isotype-Specific HDAC Inhibition (Seed Fund Project)
Bob Lahue (Galway, Ireland)
application/pdfslides Lahue 
 
14:30-14:40   CAG repeat length as a modifier (Datamining Project)
Ahmad Aziz (Bonn, Germany)
application/pdfslides Aziz 
 
14:40-14:50   Quality-Adjusted Life-Years (QALYs) and Huntington’s Disease (Datamining Project)
Colin Green (Exeter, UK)
application/pdfslides Green 
 
 

Parallel - Clinical Practice Session:
'Care for HD'
Room: Hall F2
Chair: Åsa Petersen (Lund, Sweden)
Co-Chair: Astri Arnesen (Søgne, Norway)
 
14:00-14:15   Implementation of Scottish National Care Framework
John Eden (Paisley, UK)
application/pdfslides Eden 
 
14:15-14:30 Presence and Treatment of Psychiatric Symptoms in HD
Karen Anderson (Washington D.C., USA)
application/pdfslides Anderson 
 
14:30-14:45   Caring for Carers
Győző Pék (Debrecen, Hungary)
application/pdfslides Pek 
 
14:45-15:00   Discussion
 

Short Communications I:
'Scientific Presentations: – selected from submissions'
Room: Hall E
Chair: Sandrine Humbert (Grenoble, France)
Co-Chair: Jocelyne Caboche (Paris, France)
 
15:15-16:15  
  • Huntington's Disease Phenotypes and Disrupted Corticostriatal Connectivity Observed in a Novel iPSC-Derived in Vitro Co-Culture Model
    Caroline S. Casey (London, UK)
  • Determining the CAG Repeat Mosaic in Post-Mortem Human HD Brains
    Heather Ging (London, UK)
    application/pdfslides Ging 
  • Understanding Cognitive Heterogeneity beyond Disease Burden in Huntington’s Disease
    Alice White (Cambridge, UK)
    application/pdfslides White 
  • International Guidelines in Huntington’s Disease
    Ann-Catherine Bachoud-Lévi (Creteil, France)
    application/pdfslides Bachoud-Lévi 
  • Allele specific gene editing for Huntington's Disease mediated by the KamiCas9 self-inactivating CRISPR/Cas9 system
    Nicole Déglon (Lausanne, Switzerland)
 
16:15-16:45   Tea/Coffee Break

Plenary Session II:
'Dialing Huntingtin Down'
Room: Hall E
Chair: Douglas Macdonald (Los Angeles, USA)
Co-chair: Nicole Deglon (Lausanne, Switzerland)

16:45-17:05   Gene Editing Approaches for HD Therapy
Beverly Davidson (Philadelphia, USA)
 
17:05-17:25   AAV5-miRNA HTT Lowering Therapy
Pavlina Konstantinova (Amsterdam, The Netherlands)
application/pdfslides Konstantinova 
 
17:25-17:45   HTT lowering small molecule program
Anuradha Bhattacharyya (New York, USA)
application/pdfslides Bhattacharyya 
 
17:45-18:00   Panel discussion
 

Q&A Panel Discussion
Room: Hall E
Chair: Dina de Sousa (UK)
Co-Chair: Patrick Weydt (Bonn, Germany)
 
18:15-18:45   Expert Answers to Questions of the Audience
 

Dinner on your own

Workshop "Lumbar Puncture Skills"
For Clinicans and Study Nurses
Room: Hall F2
Chairs: Jan Lewerenz (Germany), Filipe Brogueira Rodrigues (UK)
 
19:15-20:15   Improve your LP skills (registration mandatory)
application/pdfslides Rodrigues 
application/pdfslides Lewerenz 
 

Meet the Expert
For HD Family Members and Students
19:15-20:45   Several Meet the Expert Sessions

    Mental Health Problems of HD
David Craufurd, Hugh Rickards
Language: English fully booked
Room: 0.96-97

    Mental Health Problems of HD "Psychische Probleme bei HD: Ursachen, Symptome & Bewältigungsstrategien" - German session
Alzbeta Mühlbäck, Nina Hofstetter
Language: German fully booked
Room: 0.16

    Everyday Life as an HD Gene Carrier
Seth Rotberg, Michael Orth
Languages: German, English fully booked
Room: Hall N1 (Level 1)

    Clinical Trials: What does it mean to be in a clinical trial
Berry Kremer, Ralf Reilmann
Languages: Dutch, English, German fully booked
Room: Hall N2 (Level 1)

    Young People and HD: Getting the support you need
Bonnie Hennig-Trestman, Catherine Martin
Languages: English fully booked
Room: 0.14

Programme Saturday
Programme Sunday
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