|Genetic Modifiers - Dates - Meeting April 2006
EURO-HD: Genetic Modifiers working group
To be held April 20th in Cardiff, UK
will run from 9-4.30 on April 20th: we expect that most people will
travel on the 19th and we will arrange a dinner in the evening,
followed by the full scientific meeting the following day.
This is an outline of topics we
feel we need to cover – not necessarily in this order. We will also have plenty of time for
discussion built into the final programme.
of modifiers and challenges
9-9.10 Introduction Lesley Jones
Session 1: what can we learn from
Chair Oliver Bandmann
– 9.50 Jim Gusella/Marcy
MacDonald: Genetic modifier studies ongoing in the USA: MAPsibs and input into
designing fresh studies.
– 10.30 Javier Gayan: previous work
using the Venezualan pedigrees: the challenges of the analyses associated with
– 11.30 Peter Holmans: Heritability, covariate analysis, power,
nature of samples and sample size. Data
we need to collect for genetic epidemiology to detemine heritability of
– 12.00 Bernhard: how the family
relationships will be stored in the EHDN database and availability of DNA. CAG repeat resizing.
– 12.30 Discussion: what information
do we need?
the phenotypes and collecting information
1.30 – 1.50 Peter Kraus:
Motor rating scales
1.50 – 2.10 Jennifer
Humphries: Cognitive rating scales
– 2.30 Oliver Quarrell: juvenile
– 3.00 Discussion: what
information do we need?
3.00 – 3.30 Coffee
might propose as starting points:
3.30 – 3.45 Lesley Jones:
3.45 – 4.00 Oliver
Bandmann: Disease progression
4.00 – 4.30 Current state of genotyping technologies,
potential power of methods and their costs
Someone from Cardiff neuropsychiatric genetics unit.
4.30 – 5.00
Planning next moves
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