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European HD Network - External Job Offers -

Enroll-HD coordinator Leeds, UK

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An exciting new opportunity has arisen within a fascinating area of Clinical Genetics. We are seeking a research practitioner to join an established team of research staff within the Yorkshire Regional Genetics Service (YRGS).

The successful applicant will participate in the recruitment of patients into Enroll-HD which is a global, longitudinal, observational study of Huntington’s Disease and other studies relating to HD. When working on clinical trials the post holder will identify, assess, be involved in informed consent, investigations (eg. taking blood samples), monitoring the patients and observing for side effects during the course of the studies. The post holder will also be responsible for data collection and entry of information onto relevant databases.

Suitable backgrounds for the post, include research nurse or genetic counsellor, or an equivalent recognized post-graduate/registration qualification or significant experience. Further details are outlined in the accompanying Person Specification.

The successful candidate will be involved in ensuring that all research undertaken within the department safeguards the well-being of the patients and is conducted within Good Clinical Practice Guidelines for Research.

The post-holder will liaise closely with clinical staff, R&D departments and regulatory bodies, to promote sustainable YRGS research activity.

As this is a new role within the YRGS, the successful candidate will need to show considerable initiative and drive. The post holder will need to work effectively within a multi-disciplinary team and to work independently.

The post is located within the Department of Clinical Genetics of the Yorkshire Regional Genetics service and be based at Chapel Allerton Hospital, Leeds. Clinics will be held in Leeds and Hull so a clean driving license and car is essential.

For further information or an informal visit please contact Elizabeth Rowett or Dr Alison Kraus

DATA ANALYSIS / STATISTICAL MODELING POSITION AT THE ECOLE NORMALE SUPERIEURE, PARIS

The Institute for Cognitive Studies at the Ecole Normale Supérieure in Paris is seeking to fill one neuropsychology/statistical modeling position within a multidisciplinary project.

Our general aim is to design behavioral test batteries that evaluate cognitive functions (language, memory, decision making, etc) used for diagnosis/prognosis of patients with neurological dysfunctions or neurodegenerative diseases. We collect large datasets consisting in error rates and/or reaction times on a variety of tasks plus anonymized clinical descriptors of the neurological disease.

The Data Analyst/Statistical Modeler will apply a variety of statistical methods to this large dataset and implement analysis pipelines in order to provide indicators to practionners using the test batteries. The statistical methods will be principally regression methods (Generalized Linear Models/Mixed Models), with an eye on developing robust statistics and assessing the validity and reliability of these indicators (internal consistency, test-retest consistency, etc). Convergent and discriminant validity will be assessed using clinical criteria and concomitant measures of patients' health status. The reaction times will be analyzed together with binary decisions through models of noisy decision making (e.g. Ratcliff's diffusion model).

The project is hosted by the Institute for Cognitive Studies, which offers an international research setting, at the heart of the Quartier latin in Paris and in connection with the Henri Mondor Hospital near Paris at Créteil which hosts the National Center of Reference for Huntington’s disease. The research team is composed of neurologists, researchers, post-docs and PHD students from very varied background (biology, psychology, pharmacology, neurology) who are each developing a separate aspect of the project. This project will be co-coordinated by AC Bachoud-Lévi (Neuropsychologie interventionnelle) and E.Dupoux (Laboratoire de Sciences Cognitives et Psycholinguistiques).

Applicants will ideally combine:
  • a solid background in statistical analysis and/or statistical modeling
  • some experience in research in the biomedical context is appreciated but not mandatory
  • good programming skills (R, Python, or similar statistical packages or general purpose programming languages offering strong backend for numerical computation to develop statistical analyses pipelines)
  • a documented interest for team-based research,
  • creativity, independence, and productivity.


The position is for one year, with potential renewal, with salary between at 2100€ and 2800 €/month depending on prior experience. Starting dates are flexible, but the sooner will be better. Part time is possible. Women are encouraged to apply.

Candidates should send a letter of motivation (2 pages max.), the contact information of 2 to 3 referees, and a CV to bachoud@gmail.com and dupoux@gmail.com by August 10th, 2014. Interviews of short-listed candidates will be conducted from mid-August to mid September in Paris or by video-conferences.

Further information about the team can be found at: http://www.cognition.ens.fr/NPI.html